Table 1.

Diameter, centerline velocity, volumetric blood flow and wall shear rate of postcapillary and collecting venules within the dorsal skinfold chamber of antibody-treated (MAb) and vehicle-treated (Con) Syrian golden hamsters. Chambers were pretreated with TNF-α (MAb: n = 7; Con: n = 7) or PBS (MAb: n = 6; Con: n = 5). Parameters were assessed by intravital fluorescence microscopy and computer-assisted image analysis. Values are given as means ± SEM; data did not significantly differ between the groups.

	TNF-α	PBS
Diameter (μm)			TNF-α vs. PBS
Vehicle	26.4 ± 2.1	24.6 ± 0.5	p = 0.509
MAb	25.6 ± 0.6	24.3 ± 2.2	p = 0.138
Vehicle vs. MAb	p = 0.902	p = 0.177
Centerline velocity (μm/s)
Vehicle	145.9 ± 23.1	153.5 ± 32.2	p = 0.849
MAb	169.6 ± 31.6	193.3 ± 60.2	p = 0.722
Vehicle vs. MAb	p = 0.557	p = 0.596
Volumetric blood flow (pL/s)
Vehicle	52.9 ± 12.6	46.3 ± 10.7	p = 0.719
MAb	55.0 ± 10.6	58.1 ± 17.4	p = 0.600
Vehicle vs. MAb	p = 0.532	p = 0.558
Wall shear rate (s−1)
Vehicle	45.2 ± 7.2	49.6 ± 9.9	p = 0.715
MAb	53.0 ± 9.7	65.1 ± 21.5	p = 0.879
Vehicle vs. MAb	p = 0.900