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. 2004 Jan 15;113(2):200–208. doi: 10.1172/JCI19639

Figure 5.

Figure 5

Amelioration of motor defects in Hexb–/–FcRγ–/– mice. (a) When suspended by their tails, Hexb–/–FcRγ+/+ mice flexed their limbs, whereas Hexb–/–FcRγ–/– mice and Hexb+/+FcRγ+/+ mice extended their limbs. (b) Clinical scores were determined by the degree of neurological severity and counted as follows: 0 = normal, 1 = slight, 2 = mild, 3 = moderate, 4 = severe. Hexb+/+FcRγ+/+, Hexb–/–FcRγ+/+, and Hexb–/–FcRγ–/– mice were tested from 10 to 15 weeks. n = 5–10. *P < 0.05, Student’s t test (Hexb–/–FcRγ+/+ mice vs. Hexb–/–FcRγ–/– mice). Squares, Hexb–/–FcRγ+/+ mice; diamonds, Hexb+/+FcRγ+/+ mice; triangles, Hexb–/–FcRγ–/– mice. (c) Rotorod testing was performed by counting the mean time to fall from the rotating rod. n = 5–10. *P < 0.05, Student’s t test (Hexb–/–FcRγ+/+ mice vs. Hexb–/–FcRγ–/– mice). Squares, Hexb–/–FcRγ+/+ mice; diamonds, Hexb+/+FcRγ+/+mice; triangles, Hexb–/–FcRγ–/– mice.