Figure 3.

Plasma ACTH (a) and corticosterone (b) concentrations under basal conditions and after stimulation with AVP or CRH. The mice were killed by rapid decapitation 10 minutes after intraperitoneal AVP injection or 30 minutes after intraperitoneal CRH injection, and trunk blood was collected for determination of plasma ACTH and corticosterone levels. Data are expressed as mean ± SEM (basal level, n = 21 in V1bR+/+ and n = 29 in V1bR–/– mice; vehicle, AVP, and CRH stimulation, n = 8 for each genotype). *Statistically significant difference between genotypes (P < 0.05). White bars, V1bR+/+ male; black bars, V1bR–/– male.