Figure 1.

Top: Kaplan-Meier survival curves as a function of time of day of hypertension treatment, i.e., for patients with type 2 diabetes ingesting either all their blood pressure–lowering medications upon awakening or ≥1 medications at bedtime. Bottom: Hazard ratios (95% CIs) of CVD events (adjusted by age and sex) as a function of time of day of hypertension treatment, i.e., for patients with type 2 diabetes ingesting either all their blood pressure–lowering medications upon awakening or ≥1 medications at bedtime. Total events include death (from all causes), cardiovascular events (myocardial infarction, angina pectoris, and coronary revascularization), cerebrovascular events (stroke and transient ischemic attack), heart failure, and other events (acute arterial occlusion of lower extremities and thrombotic occlusion of the retinal artery). Major events include cardiovascular deaths, myocardial infarction, ischemic stroke, and hemorrhagic stroke.