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. 2011 May 21;60(6):1677–1687. doi: 10.2337/db11-0155

FIG. 6.

FIG. 6.

Effect of insulin on human umbilical vein reactivity. A: Relaxation of 62.5 mmol/L KCl-preconstricted human umbilical vein rings isolated from normal (○, □) or GDM (●, ■) pregnancies incubated (8 h) without (0 nmol/L) or with insulin, in the absence (○, ●) or presence (□, ■) of l-NAME. B: Relaxation of vessel rings with intact endothelium from normal (□) or GDM (■) pregnancies as in A, incubated (8 h) in the absence (–) or presence (+) of insulin, ZM-241385, and/or l-NAME. C: Expression of insulin receptor isoforms A (IR-A) and B (IR-B) mRNA relative to 18S rRNA (internal reference) in the number of copies in primary cultures of HUVECs from normal or GDM pregnancies incubated (8 h) in the absence (□) or presence (■) as in A. Error bars in the graphs designate the SEM.