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GAD-reactive cells stimulated on immunization of young NOD mice with incomplete Freund’s adjuvant and GAD peptide 524-543 produce IL-13. This may have many effects on a variety of tissues that include possible stimulation of a putative regulatory population of cells that expresses IL-13Rα1. Figure includes information adapted from Wynn (14) and Rasche et al. (18). MHC, major histocompatibility complex; TCR, T-cell receptor.
