Table 2.

Therapeutic responses.

	Study period I May 2005–October 2005)			Study period II (November 2005–June 2006)				p-values
	Artequick(1 (N = 17)	Artequick(2) (N = 37)	ASMQ (N = 27)	Artequick(3) N = 78)	Artequick(4) (N = 61)	Artekin (N = 97)	Coartem (N = 94)
No. of patients who dropped out	1 (6.0%)	3 (8.8%)	2 (7.5%)	15 (19.2%)	5 (8.2%)	15 (15.5%)	13 (13.8%)	NA
No. of patients with 28 days follow-up	16 (94.0%)	34 (91.2%)	25 (92.5%)	63 (80.8%)	56 (91.8%)	82 (84.5%)	81 (86.2%)	NA
No. (%) cured at 28 days	12 (75.0%)	26 (76.4%)	25 (100%)	45 (71.5%)	55 (98.2%)	81 (98.8%)	81 (100%)	<0.001
No. of treatment failures	4 (25.0%)	8 (23.6%)	0	18 (28.5%)	1 (1.8%)	1 (1.2%)	0	NA
Fever clearance time (hrs)
Mean (SD)	49.0 (16.0)	45.9 (33.1)	23.0 (14.8)	46.4 (31.0)	31.8 (12.6)	30.4 (30.0)	33.5 (23.5)	<0.001
Geometric mean parasite count (/µl)	8,334	8,247	7,314	6,434	6,408	7,499	10,042	0.315
Parasite clearance time (hrs)
Mean (SD)	56.1 (19.9)	62.7 (25.6)	51.0 (11.6)	60.1 (35.5)	51.0 (28.4)	43.0 (16.7)	52.2 (34.4)	0.027
90% Parasite clearance time (hrs)
Mean (SD)	25.6 (6.4)	23.2 (14.1)	22.4 (5.9)	28.2 (12.0)	21.3 (10.0)	21.2 (9.2)	24.0 (8.7)	<0.001
50% Parasite clearance time (hrs)
Mean (SD)	13.4 (5.9)	13.5 (9.0)	11.7 (4.6)	16.4 (9.3)	10.1 (4.5)	11.3 (5.7)	13.1 (7.0)	<0.001

Artequick⁽¹⁾: ASN: 2.4 mg/kg + PQP:14.4 mg/kg; at 0 and 24 hours, Artequick⁽²⁾: ASN: 3.2 mg/kg + PQP:16.0 mg/kg; at 0, 12 and 24 hours, Artequick⁽³⁾: ASN: 2.5 mg/kg + PQP:15.0 mg/kg; at 0 and 24 hours, Artequick⁽⁴⁾: ASN: 3.2 mg/kg + PQP:16.0 mg/kg; at 0, 24 and 48 hours, ASMQ: AS: 4.0 mg/kg + MQ: 8.0 mg/kg; at 0, 24 and 48 hours, Artekin: DHA: 2.0 mg/kg + PQP: 15.0 mg/kg; at 0, 24 and 48 hours, Coartem: ATM: 1.6 mg/kg + LFT: 9.6 mg/kg; at 0, 12, 24, 36, 48 and 60 hours

(ASN = Artemisinin, AS = Artesunate, PQP = Piperaquine, MQ = Mefloquine, DHA = Dihydroartemisinin, ATM = Artemether and LTM= Lumefantrine)