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. Author manuscript; available in PMC: 2012 Feb 18.
Published in final edited form as: Mol Cell. 2011 Feb 18;41(4):371–383. doi: 10.1016/j.molcel.2011.01.020

Figure 2.

Figure 2

DNA Damage Induction of miRNAs is Dependent on KSRP. (A) KSRP-dependent miRNAs are induced after DNA damage only in ATM-proficient cells. Human fibroblast GM0637 (ATM-proficient) and GM9607 (ATM-deficient) cells were treated with NCS (500 ng/ml) and mature miRNA levels were determined by quantitative RT-PCR. (B) KSRP-depletion abolishes the DNA damage induction of miRNAs. Control U2OS cells or U2OS cells stably overexpressing KSRP shRNA were treated with NCS and RNA samples were harvested for the expression analyses of mature miRNAs. * P < 0.05, versus the values obtained from the mock-treated controls. Error bars represent the mean ± SD in the figure.