Table 3.
RCT of five antimicrobial treatment regimens for 18 weeks duration
| Reference | No of patients | Acne severity | Treatment | Treatment difference for patient’s perception of improvement, % (95% CI) | Odds ratio, (95% CI) |
|---|---|---|---|---|---|
| Ozolins et al21 | oxytetracycline = 131 | mild-moderate | 500 mg oxytetracycline po bid (1) vs | 2 vs 1 = −1.2 (−13.3–10.9) | 0.95 (0.58–1.55) |
| minocycline = 130 | 100 mg minocycline po daily (2) vs | 4 vs 1 = 11.1 (−0.7–22.9) | 1.64 (0.98–2.74) | ||
| topical 5% BPO = 130 | topical 5% BPO bid (3) vs | 4 vs 2 = 12.3 (0.4–24.2) | 1.74 (1.04–2.90) | ||
| topical 5% BPO + 3% | topical 5% BPO + 3% | 5 vs 4 = −3.5 (−15.2–8.2) | 0.84 (0.50–1.42) | ||
| erythromycin = 127 | topical erythromycin bid (4) vs | 3 vs 1 = 5.0 (−7.0–17.0) | 1.19 (0.72–1.96) | ||
| topical 2% erythromycin in AM + topical 5% BPO in PM (5) | 3 vs 2 = 6.2 (−5.8–18.2) | 1.26 (0.76–2.08) | |||
| topical 2% erythromycin + 5% BPO = 131 |
3 vs 4 = −6.1 (−17.9–5.7) | 0.72 (0.43–1.21) |
Abbreviations: AM, morning; PM, evening; BPO, benzoyl peroxide; bid, twice daily; CI, Confidence interval; po, by mouth.