Table 2. Thermodynamic Parameters of RF and RF Antagonists Binding with RfBP in PBS (pH 7.4) at 25 °C.
system | na | KDa (nM) | ΔHa (kJ mol−1) | ΔG (kJ mol−1) | ΔS (kJ mol−1 K−1) |
---|---|---|---|---|---|
RF vs RfBP | 0.78 ± 0.02 | 5.0 ± 0.7 | −91.2 ± 5.7 | −47.5 | −0.15 |
lumiflavin vs RfBP | 1.08 ± 0.07 | 61 ± 3.5 | −48.2 ± 7.2 | −41.2 | −0.02 |
quinacrine vs RfBP | 0.90 ± 0.04 | 264 ± 22.1 | −51.6 ± 3.9 | −37.5 | −0.05 |
chloroquine vs RfBP | 1.06 ± 0.04 | 2100 ± 180 | −40.4 ± 2.9 | −32.4 | −0.03 |
perphenazine vs RfBP | no binding observed | ||||
chlorpromazine vs RfBP | no binding observed |
See Table 1.