Table 2.
Summary of T1D association results for the family collections
| Variant | Number of families |
Number of informative transmissions |
Minor allele frequency (%) in affected siblings |
Minor allele frequency (%) in unaffected parents |
Relative risk (95% C.I.) |
Family PTDT |
|---|---|---|---|---|---|---|
| rs4674297 G>A | NA | NA | NA | NA | NA | NA |
| Microsatellite (GT)n 3*>2 | 1971 | 1925 | 27.02 | 27.06 | 1.00 (0.92-1.10) | 0.87 |
| rs7573065 C>T | 2472 | 610 | 5.43 | 5.30 | 0.92 (0.78-1.08) | 0.29 |
| rs2276631 C>T | 2707 | 2587 | 27.38 | 27.15 | 1.00 (0.93-1.08) | 0.98 |
| rs3731865 G>C | 5010 | 4876 | 26.43 | 26.42 | 1.00 (0.95-1.06) | 0.98 |
| rs2279015 G>A | 2523 | 2862 | 36.33 | 36.26 | 0.94 (0.88-1.02) | 0.13 |
| rs17235409 G>A | 1859 | 198 | 2.05 | 2.10 | 0.92 (0.70-1.22) | 0.57 |
| rs17235416 TGTG>del | 2450 | 191 | 1.61 | 1.65 | 0.85 (0.64-1.14) | 0.28 |
| rs1059823 A>G | 2591 | 2950 | 39.79 | 38.81 | 1.02 (0.95-1.10) | 0.56 |
| rs1809231 C>G | 2678 | 3166 | 42.71 | 42.14 | 1.01 (0.94-1.08) | 0.78 |
Number of families with genotyping data for the variants in the SLC11A1 gene region with the respective number of informative transmissions, the relative risk and the P-value from the transmission/disequilibrium test (PTDT). [* Rare microsatellite alleles, with frequency <0.1%, were combined with the common allele 3; 95% C.I. = 95% confidence interval; NA = not available]