Table 3.
GABAB receptor binding parameters in the cerebellum and brain stem of control and experimental neonatal rats.
| Experimental groups | Cerebellum | Brain stem | ||
|---|---|---|---|---|
| Bmax (fmoles/mg protein) | Kd (nM) | Bmax (fmoles/mg protein) | Kd (nM) | |
| Control | 71.50 ± 2.41 | 11.11 ± 0.95 | 74.27 ± 1.20 | 13.31 ± 1.00 |
| Hx | 50.01 ± 1.80 a | 14.82 ± 0.82 a | 51.84 ± 1.50 a | 14.44 ± 0.99 b |
| Hx + G | 62.18 ± 1.50 b | 9.85 ± 0.36 b | 69.41 ± 1.40 b | 20.47 ± 0.99 a |
| Hx + G + O | 66.33 ± 2.00 b | 12.54 ± 0.42 | 70.47 ± 1.10 c | 26.10 ± 1.20 a |
| Hx + O | 55.34 ± 2.50 a | 15.72 ± 0.54 a | 49.10 ± 1.10 a | 16.36 ± 1.50 a |
| Hx + E | 44.02 ± 3.20 a | 10.46 ± 0.10 b | 43.59 ± 1.5 a | 14.53 ± 0.99 b |
| Hx + G + E + O | 45.50 ± 2.50 a | 7.46 ± 0.11a, b | 53.95 ± 1.5 a | 13.90 ± 0.99 b |
Values are Mean ± S.E.M of 4-6 separate experiments. Each group consist 6-8 neonatal rats.
a p < 0.001, b p < 0.05 when compared with control
c p < 0.001 when compared with hypoxic group.
Hypoxic rats- Hx, Hypoxic rats glucose treated - Hx+G, Hypoxic rats oxygen treated - Hx+O, Hypoxic rats glucose and oxygen treated - Hx+G+O, Hypoxic rats epinephrine treated - Hx + E, Hypoxic rats glucose, epinephrine and oxygen treated - Hx+G+E+O