Figure 5. Transversion mutations comprise a larger proportion of all mutations close to indels.

Transition mutations are usually the most common type of mutations, as indicated by their prevalence in the regions of sequence outside the influence of indel/region-associated mutagenicity. (A) Comparison of indel and non-indel haplotypes reveals that both exhibit the same increase in transversion substitutions with increasing proximity to the indel site. The difference between the number of transitions close to the indel (window 1) was found to be significantly lower than in sequence further from the indel (window 4) (two-sample Kolmogorov-Smirnov test, p<0.0001). (B) The proportions of each type of transversion (bottom lines) and transition (top lines) as a function of indel position. Transitions and transversions given in the legend represent substitutions in both directions (i.e., A–G includes both A–G and G–A transitions).