Table 2. Functional annotation of genes that were differentially expressed due to the effects of seizures.

Category	Term	P-value
Biological Process	Synaptic transmission	6.4e-5
	Secretory pathway	7.1e-4
	Regulation of neurotransmitter levels	0.0029
	Dopamine metabolic process	0.0043
	Protein transport	0.005
Cellular component	Coated vesicle	4.2e-4
	Cytoskeleton	0.015
	Axon	0.023
Molecular function	Transcription coactivator activity	0.019

GO analysis of the 259 differentially expressed genes that were changed due to the effect of chronic seizures on the brain. Multiple functional categories associated with transport and synaptic functions were enriched within this list of genes, suggesting that chronic seizures alter neuronal function or transmission.