Table 4. Hub genes within blue module differentially expressed due to seizures in both hippocampi.

Symbol	Name	k ME	Lesioned	Non-lesioned
Arf1	ADP-ribosylation factor 1	0.978	0.0076	0.0091
Rab5b	Rab5b, member ras oncogene family	0.973	5.2e-5	4.9e-5
Phospho2	Phosphatase, orphan 2	0.973	0.035	0.016
Ppp2ca	Protein phosphatase 2a, catalytic subunit, alpha	0.973	0.015	0.006
Zfp207	Zinc finger protein 207	0.972	1.4e-4	4.0e-4
Copa	Coatomer protein complex subunit alpha	0.972	0.0013	8.4e-4
Maea	Macrophage erythroblast attacher	0.972	0.018	0.062
Sumf1	Sulfatase modifying factor 1	0.971	0.011	0.0094
Ube2d3	Ubiquitin conjugating enzyme E2D3	0.970	0.022	0.014
Hnrnpc	Heterogeneous nuclear ribonucleoprotein C	0.970	4.9e-4	5.4e-4

The top ten most highly connected genes within the blue module and the significance (p-values) of their expression changes due to seizures in the lesioned and non-lesioned hemispheres. Genes within the table are ranked based on their k_ME within the blue module. For each gene, the last column shows the effect of seizures, which is the comparison between the animals with seizures and the animals without seizures. This comparison was performed separately in the lesioned and non-lesioned hippocampi, and the results of both analyses are shown in the table. All of these genes show similar trends towards differential expression in both the lesioned and non-lesioned hippocampi, demonstrating that their expression changes are likely caused by presence of seizures and are unrelated to the lesion.