Table 3. MC3R variants, weight loss and waist circumference change in the NUGENOB trial.

	Per-allele* weight loss change (Kg)				Per-allele* waist change (cm)
SNP	Beta coefficient	Standard error	P-value gene effects	P-value gene*diet interaction	Beta coefficient	Standard error	P-value gene effects	P-value gene*diet interaction
rs6024728	0.23	0.23	0.33	0.89	0.01	0.30	0.96	0.47
rs6014646	−0.39	0.19	0.04	0.48	−0.29	0.26	0.27	0.84
rs6024730	−0.24	0.23	0.30	0.57	−0.18	0.31	0.56	0.39
rs6024731	−0.34	0.21	0.10	0.72	−0.27	0.28	0.33	0.76
rs11697509	−0.27	0.27	0.33	0.20	0.04	0.37	0.92	0.05
rs6127698	0.25	0.18	0.15	0.81	0.23	0.23	0.32	0.62
rs3746619	−0.24	0.32	0.45	0.81	0.02	0.43	0.97	0.68
rs3827103	−0.03	0.34	0.92	0.90	0.22	0.45	0.63	0.72
rs1543873	−0.47	0.29	0.11	0.42	−0.07	0.39	0.85	0.26
rs6099058	−0.15	0.18	0.41	0.80	−0.17	0.24	0.48	0.16

*Per-allele changes were calculated using the number of the least frequent alleles for each SNP (coded a 0, 1 or 2 alleles) and under the co-dominant model adjusted for covariates (see statistical methods).