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. 2011 Jan 18;119(6):807–814. doi: 10.1289/ehp.1003013

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Association of neurodegeneration with chronic α-syn accumulation and prolonged neuroinflammation. Five months after LPS injection, Tg mice displayed significant decreases in TH levels, marked up-regulation of multiple inflammatory markers (Mac1, Iba-1, gp91, iNOS, and COX-2), and accumulation of α-syn in the SN (A and B) and striatum (C and D). NS-injected 12-month-old Tg mice did not show overt changes in levels of TH, α-syn, or inflammatory markers, in contrast with 2-month-old Tg mice. Graphs (B and D) show the ratio of densitometry values (mean ± SE) of each examined protein, and β-actin was normalized to each respective NS-injected control. All immunoblot lanes are representative samples from among at least three different animals in each group.

*p < 0.05 compared with corresponding NS-injected control mice.