Table 1.
P2X7R and inflammatory diseases
| P2X7R and renal disease | |||||
|---|---|---|---|---|---|
| Reference | Disease/ Stimulation |
P2X7 expression (Cell type) |
in vivo/ in vitro |
Species | KO/ Antagonist |
| Turner [32] | None | None | In vivo | Rat | - |
| Harada [33] | TNF-α | Mesangial cells | In vitro | Rat | - |
| Gonclaves [35] | Unilateral ureteric obstruction |
Tubular epithelial cells | In vivo | Mouse | KO |
| Vonend [34] | HTN | Glomeruli | In vivo | Rat | - |
| DM | Glomerular podocytes | In vivo | Rat | - | |
| Turner [36] | Experimental glomerulonephritis |
Glomeruli and macrophages |
In vivo | Mouse Rat |
|
| Turner [36] | Lupus Nephritis | Glomerular | In vivo | Humans | - |
| Taylor [91] | Experimental Glomerulonephritis |
In vivo | Rat Mouse |
Selective antagonist A438079 KO |
|
| Gauer [92] | None | Collecting duct alpha- and beta-intercalated cells |
In vivo | Humans | - |
| P2X7R and respiratory disease | |||||
| Reference | Disease/stimulation |
P2X7 expression (Cell type) |
in vivo/ in vitro |
Species |
KO/ Antagonist |
| Mizuno [39] | Con A | Monocytes | In vitro | Humans | oATP |
| Lemaire [93] | Polymixin B | Alveolar macrophages | In vitro | Rat | oATP |
| Wareham [40] | ATP | Lung mast cells | In vitro | Human | AZ11645373 |
| Fernando [41] | ATP-mediated mycobacterial killing |
Macrophages | In vitro | Human | Loss of function SNP |
| Kolliputi [44] | Hyperoxia | Alveolar macrophages |
in vitro and
in vivo |
Mice | oATP |
| Dellinger [48] | Asthma | ‘Whole blood’ | in vivo | Human | - |
| Muller [46] | Acute and chronic asthmatic airways inflammation |
Dendritic cells Bronchial lavage macrophages and peripheral blood eosinophils of humans |
In vivo
In vitro |
Mice and humans |
KO oATP, KN62 (in mice) |
| Lucatelli [45] | Cigarette smoke (CS)-induced lung inflammation and emphysema |
Blood and airway neutrophils, alveolar macrophages, and in whole lung tissue |
In vivo | Mice | KO KN62 |
| Riteau [47] | Bleomycin-induced lung inflammation and fibrosis |
Respiratory epithelial cells |
In vivo
In vitro |
Mice | KO In vitro A438079 and A740003 |
| P2X7R and rheumatological disease | |||||
| Reference | Disease/stimulation |
P2X7 expression (Cell type) |
in vivo/ in vitro |
Species |
KO/ Antagonist |
| Caporali [53] | Patients with RA | Synoviocytes | In vivo | Human | - |
| Al- Shukaili [54] | Patients with RA | Peripheral blood mononuclear cells produced more IL-1β |
In vitro | Human | - |
| Lopez- Castejon [57] |
ATP-induced cathepsin release |
Macrophages (Human) Bone marrow-derived macrophages (mice) release of lysosomal cathepsins |
In vitro | Humans Mice |
Antagonist (AZ10573295 and AZ11648720) KO |
| Dell’ Antonio [94] |
Arthritis was induced by the local injection of Freund’s complete medium |
Peripheral nerve endings, and in epithelial cells |
In vivo | Rats | oATP |
| Christenson [26] | SAA purified from patients with RA suppresses a-CD95 (FAS) mAb-induced human neutrophil apoptosis |
Neutrophil | In vitro | Human | oATP |