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. 2011 Feb 24;18(7):2057–2065. doi: 10.1245/s10434-010-1523-0

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© The Author(s) 2011

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Fig. 4 — Inhibition of p600 sensitizes gastric cancer cells to anoikis and reduces their viability under anchorage-independent conditions. a Cell viability assay under anchorage-independent conditions. The viability of (i) MKN45 and (ii) AGS gastric cancer cells were reduced by inhibition of p600 (MKN45, P = 0.033; AGS, P < 0.001). b Proportion of apoptotic (anoikis) cells under anchorage-independent conditions in (i) control siRNA-transfected MKN45 cells and (ii) p600-targeting siRNA-transfected MKN45 cells as analyzed by flow cytometry. c Proportion of apoptotic (anoikis) cells in (i) control siRNA-transfected AGS cells and (ii) p600-targeting siRNA-transfected AGS cells as analyzed by flow cytometry. d Macroscopic appearance of colonies formed in soft agar; (i) control siRNA-transfected MKN45 cells and (ii) p600-targeting siRNA-transfected MKN45 cells. (iii) Number of colonies. e Macroscopic appearance of colonies formed in soft agar; (i) control siRNA-transfected AGS cells and (ii) p600-targeting siRNA-transfected AGS cells. (iii) Data graph. Data are expressed as mean ± SD. The number of colonies was reduced by inhibition of p600 (MKN45, P < 0.001; AGS, P = 0.003)