Fig. 5.

Inhibition of p600 suppresses the establishment of intraperitoneal disseminated tumors. a Macroscopic appearance of the intraperitoneal disseminated nodules; (i) control siRNA-transfected MKN45 cells injected into SCID mice, and (ii) p600-targeting siRNA-transfected MKN45 cells (n = 10/group). Arrows indicate intraperitoneal disseminated nodules. (iii) Resected disseminated nodules from SCID mice. b Data graph. Data are expressed as mean ± SD. The number of intraperitoneal disseminated nodules was significantly reduced by p600 inhibition (P < 0.001)