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. 2011 Jan 21;90(2):234–242. doi: 10.1093/cvr/cvr015

Table 2.

Possible mechanisms of mitochondrial dysfunction in pathological hypertrophy

Potential mechanisms of mitochondrial dysfunction in pathological hypertrophy
ROS
Altered ANT expression
Cardiolipin loss or peroxidation
Fatty acid and lipid overload
Mitochonrial uncoupling
Impaired mitochondrial biogenesis
Reduced transcriptional signalling of regulators of mitochondria