Table 3.
Effects of Melissa officinalis pre-treatments (gavage) on MNPCE frequencies (mean ± SD) in the bone marrow of mice, following intra-peritoneal injection with saline or methyl methanesulfonate (MMS) 40 mg/kg.
| Treatment | Number of analyzed cells | PCE/NCE ratio | MNPCEs | p values |
|---|---|---|---|---|
| Negative Control | 1000 | 230.6 ± 4.51 | 3.6 ± 0.89 | - |
| Positive Control | 1000 | 231.8 ± 7.73 | 5.2 ± 1.79 | 0.05a |
| Mo-EE 250 mg + MMS | 1000 | 233.8 ± 9.42 | 3.6 ± 1.67 | 0.09 |
| Mo-EE 500 mg + MMS | 1000 | 239.0 ± 3.46 | 2.5 ± 2.52 | 0.05a |
| Mo-EE 500 mg + saline | 1000 | 236.8 ± 7.89 | 3.2 ± 2.28 | - |
| Mo-AE + saline | 1000 | 227.0 ± 5.39 | 3.2 ± 1.79 | - |
| Mo-AE + MMS | 1000 | 226.4 ± 5.13 | 6.4 ± 1.67 | 0.15 |
Mo-EE = ethanolic extract of Melissa officinalis; Mo – AE = aqueous extract of M. officinalis PCE = polychromatic erythrocytes NCE = normochromatic erythrocytes.
a
Values differing significantly from positive control (Student t-test).