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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: J Pediatr. 2011 Feb 23;159(1):143–149.e2. doi: 10.1016/j.jpeds.2010.12.037

Figure 2.

Figure 2

The combined impact of prenatal diagnosis and folic acid utilization on the number of NTDs. The top line of this figure gives an estimate of the neural tube defect cases that would have occurred without folic acid supplementation, fortification, and other unknown factors. The top line was calculated based on the 1992 prevalence rates. *Statewide numbers for this year (1992–1993) extrapolated from surveillance in a 14 county area. All other years are actual surveillance numbers for the entire state. The outcome of three NTD-affected pregnancies is not known. Thin arrow = fortification in South Carolina; thick arrow = mandatory fortification in the US.[C1]