Table 1.
Neural tube defect (NTD) numbers and rates1 per 1,000 live births and fetal deaths in South Carolina, by project year2 and type, 1992–2009
| TYPE OF NTD | 92–932 | 93–94 | 94–95 | 95–96 | 96–97 | 97–98 | 98–99 | 99–00 | 00–01 | 01–02 | 02–03 | 03–04 | 04–05 | 05–06 | 06–07 | 07–083 | 08–09 | TOTAL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ISOLATED SPINA BIFIDA |
14 0.85 |
37 0.69 |
30 0.57 |
23 0.44 |
28 0.54 |
18 0.33 |
16 0.28 |
20 0.34 |
16 0.27 |
16 0.27 |
13 0.22 |
14 0.23 |
19 0.30 |
18 0.29 |
20 0.31 |
18 0.29 |
17 0.29 |
337 0.36 |
| SPINA BIFIDA WITH ANOMALIES |
2 0.12 |
4 0.08 |
2 0.04 |
2 0.04 |
4 0.08 |
2 0.04 |
1 0.02 |
5 0.09 |
8 0.13 |
6 0.10 |
8 0.13 |
5 0.08 |
3 0.05 |
3 0.05 |
8 0.13 |
1 0.02 |
7 0.12 |
71 0.08 |
| TOTAL SPINA BIFIDA |
16 0.97 |
41 0.77 |
32 0.61 |
25 0.48 |
32 0.61 |
20 0.36 |
17 0.30 |
25 0.43 |
24 0.40 |
22 0.37 |
21 0.35 |
19 0.31 |
22 0.35 |
21 0.34 |
28 0.44 |
19 0.31 |
24 0.40 |
408 0.43 |
| ISOLATED ANENCEPHALY |
7 0.42 |
27 0.51 |
17 0.32 |
24 0.46 |
30 0.58 |
13 0.24 |
15 0.26 |
23 0.39 |
17 0.28 |
13 0.22 |
11 0.18 |
19 0.31 |
14 0.22 |
18 0.29 |
15 0.24 |
27 0.44 |
14 0.24 |
304 0.32 |
| ANENCEPHALY WITH ANOMALIES |
4 0.24 |
3 0.06 |
4 0.08 |
4 0.08 |
1 0.02 |
8 0.15 |
6 0.11 |
1 0.02 |
5 0.08 |
9 0.15 |
3 0.05 |
3 0.05 |
0 0.00 |
3 0.05 |
2 0.03 |
8 0.13 |
1 0.02 |
65 0.07 |
| TOTAL ANENCEPHALY |
11 0.66 |
30 0.56 |
21 0.40 |
28 0.54 |
31 0.59 |
21 0.38 |
21 0.37 |
24 0.41 |
22 0.37 |
22 0.37 |
14 0.23 |
22 0.36 |
14 0.22 |
21 0.34 |
17 0.27 |
35 0.57 |
15 0.25 |
369 0.39 |
| ISOLATED ENCEPHALOCELE |
3 0.18 |
3 0.06 |
9 0.17 |
7 0.13 |
5 0.10 |
7 0.13 |
8 0.14 |
4 0.07 |
4 0.07 |
2 0.03 |
3 0.05 |
3 0.05 |
6 0.10 |
5 0.08 |
7 0.11 |
6 0.10 |
4 0.07 |
86 0.09 |
| ENCEPHALOCELE WITH ANOMALIES |
1 0.06 |
6 0.11 |
4 0.08 |
4 0.08 |
2 0.04 |
4 0.07 |
2 0.04 |
1 0.02 |
3 0.05 |
5 0.08 |
4 0.07 |
2 0.03 |
2 0.03 |
3 0.05 |
3 0.05 |
3 0.05 |
4 0.07 |
53 0.06 |
| TOTAL ENCEPHALOCELE |
4 0.24 |
9 0.17 |
13 0.25 |
11 0.21 |
7 0.13 |
11 0.20 |
10 0.18 |
5 0.09 |
7 0.12 |
7 0.12 |
7 0.12 |
5 0.08 |
8 0.13 |
8 0.13 |
10 0.16 |
9 0.15 |
8 0.13 |
139 0.15 |
| ISOLATED NTDS | 24 1.45 |
67 1.26 |
56 1.07 |
54 1.03 |
63 1.21 |
38 0.69 |
39 0.69 |
47 0.80 |
37 0.62 |
31 0.53 |
27 0.45 |
36 0.59 |
39 0.62 |
42 0.69 |
42 0.66 |
51 0.83 |
35 0.59 |
728 0.77 |
| NTDS WITH ANOMALIES |
7 0.42 |
13 0.24 |
10 0.19 |
10 0.19 |
7 0.13 |
14 0.25 |
9 0.16 |
7 0.12 |
16 0.27 |
20 0.34 |
15 0.25 |
10 0.16 |
5 0.08 |
8 0.13 |
13 0.20 |
12 0.20 |
12 0.20 |
188 0.20 |
| TOTAL NTDS | 31 1.87 |
80 1.50 |
66 1.26 |
64 1.22 |
70 1.34 |
52 0.95 |
48 0.85 |
54 0.92 |
53 0.88 |
51 0.87 |
42 0.70 |
46 0.75 |
44 0.70 |
50 0.82 |
55 0.86 |
63 1.03 |
47 0.79 |
916 0.97 |
1
The decrease in the rate ratio over the 17 years is significant for spina bifida (P<0.0001), for anencephaly (P<0.0009), for isolated NTDs (P<0.0001), and for total NTDs (P<0.0001), but not for encephalocele (P<0.0586) nor NTDs with associated anomalies (P <0.2803).
2
Project years = October through September, year 1 ending September 1993, year 17 ending September 2009
3
Anencephaly numbers for this period include 6 terminations in Georgia that we are not able to confirm.