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Initial rates for 258 nM DNMT1, 6 μg poly(dIdC), 300 μL total volume at room temperature and at 37 °C measured by discontinuous assay: (A) 682 nM AdoMet, luciferase-linked AdoHcy assay. (B) 672 nM [methyl-3H]-AdoMet, radiometric filter paper assay.