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Overlay of the 2D 1H-1H TOCSY spectra of hIAPP1–19 in solution and a select region of the NOESY spectra in the absence (red) and presence (blue) of 10 mM ZnCl2. Addition of zinc causes downfield shifts for the HN proton residues of Cys 7, Glu 10, Ala 13, Leu 16, Val 17 and upfield shifts for residues Arg 11 and His 18. A significant up-field shift of 0.2 ppm for the Hδ2 proton of His 18 is observed upon the addition of zinc (shown in the NOESY strip).
