Table 1.
Peptide and buffer | Kd(μM) | ΔG (kJ/mole) | ΔH (kJ/mol) | ΔS (J/mol) | n (zinc:peptide) |
---|---|---|---|---|---|
hIAPP 1–19 in low ionic strength buffer (100μM NaCl) | 1.12 ± 0.2 | −33.9 ± 0.3 | −61.9 ± 2.4 | −93.8 ± 8.1 | 0.136 ± 0.004 |
hIAPP 1–19 in low ionic strength buffer (100μM NaCl) with 30% TFE | 2.26 ± 1.6 | −32.2 ± 1.4 | −56.1 ± 8.3 | −80.2 ± 28.1 | 0.241 ± 0.023 |
hIAPP 1–19 in high ionic strength buffer (100 mMNaCl) | 1.23 ± 0.5 | −33.7 ± 0.8 | −25.6 ± 2.2 | +27.2 ± 7.9 | 0.151 ±0.009 |