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. Author manuscript; available in PMC: 2012 Jul 8.
Published in final edited form as: J Mol Biol. 2011 May 17;410(2):294–306. doi: 10.1016/j.jmb.2011.05.015

Table 1.

Apparent thermodynamic parameters obtained from ITC titration of ZnCl2 into peptide.

Peptide and buffer Kd(μM) ΔG (kJ/mole) ΔH (kJ/mol) ΔS (J/mol) n (zinc:peptide)
hIAPP 1–19 in low ionic strength buffer (100μM NaCl) 1.12 ± 0.2 −33.9 ± 0.3 −61.9 ± 2.4 −93.8 ± 8.1 0.136 ± 0.004
hIAPP 1–19 in low ionic strength buffer (100μM NaCl) with 30% TFE 2.26 ± 1.6 −32.2 ± 1.4 −56.1 ± 8.3 −80.2 ± 28.1 0.241 ± 0.023
hIAPP 1–19 in high ionic strength buffer (100 mMNaCl) 1.23 ± 0.5 −33.7 ± 0.8 −25.6 ± 2.2 +27.2 ± 7.9 0.151 ±0.009