Scheme 3.
Reagents and conditions: (a) (COCl)2, DMF, DCM; (b) Me(OMe)NH·HCl, NEt3, DCM; (c) MeMgBr, THF; (d) Br2, HOAc/HBr; (e) arylthiourea 58, EtOH; (f) TMSCH2N2, THF; then HBr. $ = commercially available.
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