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. 2011 May 3;152(7):2909–2919. doi: 10.1210/en.2010-1490

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Copyright © 2011 by The Endocrine Society

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Fig. 2. — Exposure effects on mRNA expression in liver of P15 pups. A, CYP1A1 mRNA expression in liver was significantly induced by all treatments but PTU (F_6,33 = 75.74; P < 0.0001). However, pups treated with PCB mixtures containing PCB126 exhibited significantly greater CYP1A1 mRNA induction than pups in the other groups. B, S14 mRNA levels were significantly different among the treatment groups (F_6,31 = 8.727; P < 0.0001). S14 mRNA levels were greatest in animals treated with A1254 and with PCB 105/118/126. C, ME mRNA also was significantly different among the treatment groups (F_6,31 = 7.263; P < 0.0001). D, D1 mRNA levels were significantly affected by treatment (F_6,33 = 7.023; P < 0.0001). D1 mRNA levels were significantly reduced by A1254, PTU, and those PCB mixtures containing PCB126. Bartlett's test showed unequal variance of data sets for CYP1A1 and S14, so the data were log transformed for the purpose of statistical analysis only. E, Regression analysis revealed a strong nonlinear correlation between CYP1A1 mRNA levels and the mRNA encoding S14 (r² = 0.5616) and ME (r² = 0.4691). F, A weaker positive linear correlation was observed between serum total T₄ levels and S14 (r² = 0.1312), but this was not observed with ME mRNA levels (r² = 0.05417).