Fig. 3.
Exposure effects on mRNA expression in pituitary of P15 pups. A, CYP1A1 mRNA was significantly affected by treatments (F6,33 = 28.85; P < 0.0001). Interestingly, mixtures of three PCB congeners containing PCB 126 produced the greatest induction of CYP1A1 mRNA. B, TSHβ mRNA was significantly affected by treatment (F6,33 = 6.172; P = 0.0002); it was increased in PTU-treated animals. C, GH mRNA levels were significantly affected by treatment (F6,33 = 3.345; P = 0.0011); it was significantly reduced in PTU-treated animals. D, CYP1A1 mRNA levels were weakly associated with mRNA expression of TSHβ (r2 = 0.03361) but not GH (r2 = 0.0071). E, Serum total T4 levels were negatively associated with TSHβ mRNA (r2 = 0.1365) and positively associated with GH mRNA levels (r2 = 0.2001).