Fig. 6.

Prepuce hyperplasia by constitutively activated hedgehog signal in the female GT. A and B, The female GT of R26SmoM2 mutant embryos shows a prepuce hyperplasia, particularly in its ventral side (arrow). In the mutant embryos, a slit-like structure is observed in the ventral midline of the GT (A, arrowhead) as a consequence of improper incorporation of the urethra into the glans region (B, arrowhead). C, No significant differences of p450Scc expression are observed between mutant and control ovaries, whereas high level of its expression is detected in the control male testis.