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. Author manuscript; available in PMC: 2011 Jun 15.
Published in final edited form as: Ann N Y Acad Sci. 2009 Oct;1179:120–143. doi: 10.1111/j.1749-6632.2009.05011.x

Figure 5.

Figure 5

Major intracellular signal transduction pathways for CRF1 and CRF2 receptors. While the dominant mode of signaling for both CRF receptors signaling is Gs-coupled AC-PKA cascade, they may also signal via the PLC-PKC and ERK-MAPK cascades. CRF receptor AC-PKA signaling is stringently regulated by GRK- and arrestin-mediated homologous desensitization. Although the mechanisms regulating CRF receptor ERK-MAPK signaling are not yet fully understood, this pathway may potentiate BDNF-stimulated TrkB receptor function. (In color in Annals online.)