Table 2. Plasma APTT and thrombin time measurements following administration of vehicle, WE or tPA.
Treatment | APTT | Thrombin time |
---|---|---|
Vehicle | 25.2±0.9 | 13.6±0.5 |
WE | 26.2±1.1 | 14.7±0.6 |
tPA | 27.8±0.8 | 13.3±0.4 |
Anesthetized mice were administered a bolus of vehicle, WE (25 μg/kg), or tPA (2.5 mg/kg). Fifteen minutes after administration, blood was drawn into sodium citrate and plasma prepared by centrifugation. Plasma APTT and thrombin times were measured at 10.0±1.0 and 10.5±1.0 minutes, respectively, after the blood draw. Values are mean±SEM from 5-6 experiments.