Table 1.
Threshold levels of the core set measures for remission according to the survey of committee members.*
| Highest level of the core set measure that would be compatible with remission: | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| If it were the only measure assessed | If all other measures pointed to remission | |||||||||
| Core set measure† | mean (SD) | min | med | 80% | max | mean (SD) | min | med | 80% | max |
| TJC28 | 1.1 (1.3) | 0 | 1 | 2 | 6 | 2.6 (2.0) | 1 | 2 | 4 | 10 |
| Full TJC (68 joints) | 1.6 (1.5) | 0 | 2 | 2 | 6 | 2.6 (2.0) | 1 | 2 | 4 | 10 |
| SJC28 | 0.5 (0.9) | 0 | 0 | 1 | 4 | 1.3 (1.3) | 0 | 1 | 2 | 6 |
| Full SJC (66 joints) | 0.6 (0.9) | 0 | 0 | 1 | 4 | 1.4 (1.2) | 0 | 1 | 2 | 6 |
| ESR (mm/h) | 21 (6) | 10 | 20 | 25 | 30 | 25 (6) | 20 | 25 | 30 | 40 |
| CRP (mg/dL) | 0.9 (0.4) | 0 | 1 | 1 | 2 | 1.1 (0.6) | 0 | 1 | 1.5 | 2 |
| Pain (0-10 scale) | 1.3 (0.7) | 0 | 1 | 2 | 3 | 2.4 (1.3) | 1 | 2 | 3 | 6 |
| PhGA (0-10 scale) | 1.0 (0.9) | 0 | 1 | 1 | 4 | 1.6 (1.0) | 0 | 2 | 2 | 4 |
| PtGA (0-10 scale) | 1.2 (0.8) | 0 | 1 | 2 | 3 | 2.2 (1.3) | 0 | 2 | 3 | 6 |
| HAQ (0-3 scale) | 0.7 (0.7) | 0 | 0.5 | 0.5 | 3 | 0.9 (0.8) | 0.2 | 0.6 | 1 | 3 |
*
27 committee members responded to the survey: 25 experienced RA clinical researchers and two patients. The columns following the mean report minimum, median, 80th percentile and maximum.
†
TJC, tender joint count, SJC, swollen joint count (For example, TJC28 means tender joint count of 28 joints). ESR, Erythrocyte sedimentation rate. CRP, C-reactive protein. PhGA, physician/observer global assessment. PtGA, patient global assessment. HAQ, Health Assessment Questionnaire.