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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Int J Dev Neurosci. 2011 Feb 21;29(3):215–223. doi: 10.1016/j.ijdevneu.2011.02.006

Figure 2.

Figure 2

Some of the DNC signaling pathways that regulate PFC network strength, and their relationship to schizophrenia; mechanisms that strengthen connectivity are shown in green; those that weaken connectivity are shown in red. Genetic alterations in patients with schizophrenia frequently involve DNC proteins that normally serve to strengthen pyramidal cell connections, and to inhibit stress signaling pathways (shown in purple). Thus, these genetic insults would weaken PFC network connections and increase vulnerability to stress exposure. Adapted from (Arnsten et al., 2010).