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. 2011 Jun 13;193(6):1101–1114. doi: 10.1083/jcb.201103132

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© 2011 Gruschke et al.

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Figure 9. — Hypothetical model for the role of the Cbp3–Cbp6 complex during biogenesis of cytochrome b. In the absence of an mRNA, the Cbp3–Cbp6 complex is bound to mitochondrial ribosomes (state 0). COB mRNA binds to the ribosome, and translation can only be initiated efficiently when the Cbp3–Cbp6 complex is ribosome bound (state 1). Cbp3 and Cbp6 then interact with the newly synthesized cytochrome b. Cbp4 is recruited (state 2), and this complex mediates the assembly of cytochrome b into a functional bc₁ complex. IMM, inner mitochondrial membrane; IMS, intermembrane space.