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. 2011 May 17;10:57. doi: 10.1186/1476-4598-10-57

Figure 2.

Figure 2

Silencing of Siah2 or POSH enhances caspase activity in response to TRAIL. a: qRT-PCR assessment of Siah2 and POSH targeting in PC-3 and PPC-1 cells 24 hours after siRNA transfection. b: Caspase-8 activity in PC-3 cells transfected with siRNA specific for Siah2 or POSH for 72 hours and treated with TRAIL (100 ng/mL) for 2 and 4 hours. c: Caspase-3/7 activity in PC-3 cells treated as in (B) for 24 hours. Statistical comparison was made using a two-tailed Student's t-test. **P < 0.01, ***P < 0.001.