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. 2011 May 17;11:173. doi: 10.1186/1471-2407-11-173

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Copyright ©2011 Davis et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Somatic alteration of MAP2K4 in ovarian cancer. A. Homozygous deletions (red bars) over the MAP2K4 region detected by Affymetrix SNP array. B. An aberrant shift was detected by HRM (red trace) compared with the matching normal DNA and the other tumor samples (blue traces). C. The sequence trace of re-amplified, non-WGA tumor DNA (IC489T) compared to normal (IC489N) shows a 16 bp homozygous deletion in exon 7 (red box), which causes a frameshift alteration leading to premature termination of the protein as indicated by the sequence below.