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. Author manuscript; available in PMC: 2012 May 13.
Published in final edited form as: Circ Res. 2011 May 13;108(10):1252–1269. doi: 10.1161/CIRCRESAHA.110.236067

Figure 2. Gradients of disease prevalence, MAFs and effect sizes.

Figure 2

The prevalence of disease, number of genetic determinants and the effect sizes of the DSVs are depicted as continuums. Single gene disorders are caused by rare variants with large effect sizes. Typically, several other variants also expected to contribute to phenotypic expression of the diseases. On the opposite end of the spectrum are the common complex traits, which are caused by a very large number of genetic variants, each imparting a modest effect size.