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. Author manuscript; available in PMC: 2012 May 13.
Published in final edited form as: Circ Res. 2011 May 13;108(10):1252–1269. doi: 10.1161/CIRCRESAHA.110.236067

Figure 3. Relationship between effect sizes of DSVs and proximity of the phenotype.

Figure 3

The influence of genetic variants is expected to correlate inversely with the proximity of the phenotype to genes. The effect size is greater for the proximal phenotypes, such as mRNA levels than for distant phenotypes, such as mortality, wherein a large number of competing genetic and non-genetic determinants contribute to the phenotype.