Table 1. Activity of MS-0022 and deletion/substitution analogs (See structure in figure 1A).

ID	R1	R2	R3	MW	IC50 (Shh-L2, nM)
MS-0022	8-methylimidazo[1,2-a]pyridine	–	2-bromophenyl	406.3	100
MS-0011	8-methylimidazo[1,2-a]pyridine	–	Methyl	265.3	>20,000
MS-0012	8-methylimidazo[1,2-a]pyridine	–	2-propyl	293.4	>20,000
MS-0013	–	O-Amide	2-bromophenyl	319.2	>20,000
MS-0014	Propyl	–	2-bromophenyl	318.2	10,000
MS-0015	6-morpholinopyridazin-3-yl	–	2-bromophenyl	439.3	800
MS-0016	(6-phenylpyrimidin-4-yl)amino	–	2-bromophenyl	445.3	2000
MS-0017	naphthalen-2-ylcarbamoyl	–	2-bromophenyl	445.3	280
MS-0018	2-benzylidenehydrazinecarbonyl	–	2-bromophenyl	442.3	5000

Table depicting molecular weight and bological activity (nM IC50) of deletion or substitution analogs of MS-0022 as measured by pathway inhibition in Shh induced Shh-L2 cells.