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. 2011 Jun 15;6(6):e20953. doi: 10.1371/journal.pone.0020953

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Bereswill et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Gnotobiotic wildtype (WT; C57BL/10 (C10) or C57BL/6 (C6) as indicated), TLR4^−/− (lower panel), TLR9^−/−, TRIF^−/−, and MyD88^−/− (upper panel) mice generated by antibiotic gut decontamination were orally infected with C. jejuni strain ATCC 43431. The average numbers of apoptotic cells (positive for caspase-3, panel A), neutrophilic granulocytes (neutrophils, positive for MPO-7, panel B), T-lymphocytes (positive for CD3, panel C), regulatory T-cells (Tregs, positive for FOXP3, panel D) and B-lymphocytes (positive for B220, panel E) from at least six high power fields (HPF, 400× magnification) per animal were determined microscopically in immunohistochemically stained colon sections. Numbers of animals of the respective genotype analyzed are given in parentheses. Means (black bars) and levels of significance (P-values) as compared to the respective infected WT control group (determined by the Student's t-test) are indicated. Data shown were pooled from three independent experiments.