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. 2011 Jun 15;6(6):e21018. doi: 10.1371/journal.pone.0021018

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) The binding of chimeric rabbit/human IgG1 R11, R12, Y31, and P14 to immobilized human ROR1 (Fc-hROR1), mouse ROR1 (Fc-mROR1), and human ROR2 (hROR2-Fc) was analyzed by ELISA using goat anti-human kappa pAbs conjugated to HRP. The binding of goat anti-human ROR2 pAbs (gahROR2) was detected with donkey anti-goat IgG (H+L) pAbs conjugated to HRP. (B) Using the same procedure, the epitopes of IgG1 R11, R12, and Y31 were mapped with five immobilized Fc fusion proteins that consisted of just one or two extracellular domains of human ROR1 (see Fig. 1 ). These were Fc-hROR1ig (ig), Fc-hROR1fz (fz), Fc-hROR1kr (kr), Fc-hROR1ig+fz (ig+fz), and Fc-hROR1fz+kr (fz+kr). Columns indicate mean values and error bars indicate standard deviation values of side-by-side triplicates.