Figure 7. Determination of sIgE to MUXF (CCD) was not appropriate to distinguish between true and CCD-based double sensitization.

Patients with true DS in the WB (sensitization to major allergens or hyaluronidase) had detectable sIgE to MUXF and conversely, patients with a verified CCD-based DS by the WB inhibition had no detectable sIgE to MUXF. As the coincidence of true DS and detectable sIgE to MUXF was high, results could be misinterpreted and true DS could be easily overlooked.