Table 4. Carrier frequencies of HLA-DRB1in the Indian ethnic group by ACPA status.
| Indian | ||||
| Cases (n = 296(%) | Controls (n = 213)(%) | OR, 95% CI§ | P value (Pc) | |
| DRB1*01 | ||||
| ACPA-positive | 12(6) | - | 2.20(0.81–5.98) | |
| ACPA-negative | 4(4) | 6(3) | 1.50(0.41–5.44) | |
| DRB1*03 | ||||
| ACPA-positive | 19(10) | - | 1.01(0.52–1.96) | |
| ACPA-negative | 15(19) | 20(9) | 1.79(0.87–3.66) | |
| DRB1*04 | ||||
| ACPA-positive | 69(35) | - | 1.55(1.01–2.37) | NS (NS) |
| ACPA-negative | 26(27) | 54(25) | 1.09(0.63–1.89) | |
| DRB1*07 | ||||
| ACPA-positive | 45(23) | - | 0.79(0.51–1.25) | |
| ACPA-negative | 20(21) | 57(27) | 0.72(0.40–1.28) | |
| DRB1*08 | ||||
| ACPA-positive | 12(6) | - | 0.98(0.44–2.21) | |
| ACPA-negative | 8(8) | 13(6) | 1.40(0.56–3.49) | |
| DRB1*09 | ||||
| ACPA-positive | 7(4) | - | 3.83(0.79–18.64) | |
| ACPA-negative | 2(2) | 2(1) | 2.24(0.31–16.18) | |
| DRB1*10 | ||||
| ACPA-positive | 75(38) | - | 2.60(1.66–4.06) | 2×10−5 (3×10−4) |
| ACPA-negative | 21(22) | 40(19) | 1.21(0.67–2.19) | |
| DRB1*11 | ||||
| ACPA-positive | 10(5) | - | 0.61(0.27–1.36) | |
| ACPA-negative | 5(5) | 17(8) | 0.63(0.23–1.77) | |
| DRB1*12 | ||||
| ACPA-positive | 7(4) | - | 0.42(0.17–1.03) | |
| ACPA-negative | 9(9) | 17(8) | 1.19(0.51–2.78) | |
| DRB1*13 | ||||
| ACPA-positive | 16(8) | - | 0.33(0.18–0.61) | 3×10−3 (3×10−2) |
| ACPA-negative | 18(19) | 44(21) | 0.89(0.48–1.63) | |
| DRB1*14 | ||||
| ACPA-positive | 34(17) | - | 0.81(0.49–1.33) | |
| ACPA-negative | 19(20) | 43(20) | 0.98(0.53–1.78) | |
| DRB1*15 | ||||
| ACPA-positive | 87(44) | - | 1.28(0.86–1.90) | |
| ACPA-negative | 43(45) | 80(38) | 1.35(0.83–2.20) | |
| DRB1*16 | ||||
| ACPA-positive | 3(2) | - | 1.61(0.27–9.72) | |
| ACPA-negative | 0(0) | 2(1) | 0.55(0.02–12.30) | |
*The frequency of DRB1 genotypes in ACPA subgroups was calculated as the number of ACPA-positive or ACPA-negative RA cases for a specific DRB1 allele divided by the total number of cases within that ACPA subgroup (Indian: 200 ACPA-positive RA cases and 96 ACPA-negative RA cases).
§Individuals without the allele being investigated were used as the reference group for the calculation of odds ratio (OR) and 95% confidence interval (95% CI).
Corrected p (pc) values were obtained by multiplying the uncorrected p values by 13.
NS: not significant.