Table 7. Risk of developing ACPA-positive or ACPA-negative RA among carriers of SE (single, double or any) in the MyEIRA study population by ethnicity.

	No SE*		Single SE			Double SE			Any SE
	Cases	Controls	Cases	Controls	OR (95% CI)	Cases	Controls	OR (95% CI)	Cases	Controls	OR (95% CI)
Malay
ACPA-positive	140	600	100	79	5.29 (3.74–7.48)	16	4	17.14(5.64–52.07)	116	83	5.85(4.18–8.18)
ACPA-negative	119		30		1.87 (1.18–2.97)	0		1.78 (1.12–2.82)	30		1.82(1.15–2.89)
Chinese
ACPA-positive	72	147	54	17	6.49 (3.51–11.98)	6	0	0.00(-)**	60	17	7.20 (3.92–13.23)
ACPA-negative	62		9		1.26 (0.53–2.97)	1		0.00(-)#	10		4.74 (0.16–143.20)
Indian
ACPA-positive	88	148	98	56	2.75 (1.81–4.16)	14	5	4.71 (1.64–13.52	112	61	2.89 (1.93–4.34)
ACPA-negative	65		29		1.10 (0.65–1.87)	2		1.09 (0.65–1.82)	31		0.91 (0.17–4.82)

*Cases and controls without SE genes were used as reference groups.

**Fisher exact two-tailed p value, p = 0.0015.

#Fisher exact two-tailed p value, p = 0.3, NS.