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. 2011 Jun 15;6(6):e21229. doi: 10.1371/journal.pone.0021229

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(A) E2 levels in sera from 4 week old mice treated with vehicle or DAS for 48 hrs are shown. * p<0.05 for vehicle-injected group versus DAS-injected group. (B) Estrone sulfate levels in sera from 8 week old female mice treated with vehicle or DAS for 48 hrs are shown. (C) The clearance of exogenously administered E2 from mice sera was analyzed using DAS treated and vehicle treated ovariectomized mice. Ovariectomized mice were given DAS via gavage and E2 (0.5 mg/kg) was injected subcutaneously 42 hrs after the DAS administration. The E2 content in serum was determined by radioimmunoassay and plotted against time after E2 treatment. **, p<0.01 for vehicle-injected group versus DAS-injected group at 3 hrs after E2 treatement.