Table 3.

Specific types of structural aberrations detected by DAPI analysis of MI and MII spermatocytes after exposure of male mice to ET

Dose, mg/kg	Harvest time	Metaphase	No. cells analyzed	Types of chromosomal aberrations
				Multiple aberrations		Centromere fragmentation		Breaks at centromere		Chromatid fragments		Chromatid exchanges		Chromosome fragments
				No.	%	No.	%	No.	%	No.	%	No.	%	No.	%
0		MI	315	0	0	0	0	1	0.3	0	0	0	0	1	0.3
		MII	268	0	0	0	0	1	0.4	4	1.5	0	0	0	0
80	6 h	MI	261	23	8.8	48	18.4	1	0.4	7	2.7	5	1.9	11	4.2
		MII	242	26	10.7	0	0	6	2.5	68	28.1	0	0	2	0.8
80	16 h	MI	320	71	22.1	10	3.1	15	4.7	6	1.9	23	7.2	16	5.0
		MII	229	28	12.2	0	0	18	4.7	53	23.1	0	0	0	0
80	40 h	MI	358	112	31.3	4	1.1	11	3.1	3	0.8	32	8.9	29	8.1
		MII	158	21	13.3	0	0	7	4.4	61	38.6	0	0	0	0
80	64 h	MI	303	32	10.6	0	0	9	3.0	7	2.3	18	5.9	15	4.9
		MII	210	7	3.3	0	0	10	4.8	48	22.8	0	0	1	0.5
80	10 d	MI	200	6	3.0	2	1.0	2	1.0	0	0	5	2.5	4	2.0
		MII	219	0	0	0	0	5	2.3	7	2.3	0	0	0	0