Table 6.
Structural and numerical chromosome abnormalities detected by PAINT/DAPI analysis in mouse first-cleavage zygotes after exposure of male mice to ET
| Dose, mg/kg | Days post ET | Structural aberrations
|
Numerical
abnormalities
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total no. zygotes | No. with aberrations | % ± SEM | Total no. zygotes | Hypoploidy
(N = 36–39)
|
Diploidy
(N = 40)
|
Hyperploidy
(N = 41)
|
|||||
| No. | % | No. | % | No. | % | ||||||
| 0 | 318 | 2 | 0.6 ± 0.3 | 303 | 29 | 9.6 ± 2.3 | 268 | 88.4 | 1 | 0.3 ± 0.5 | |
| 80 | 6.5 | 180 | 2 | 1.1 ± 1.0 | 170 | 17 | 10.0 ± 6.1 | 153 | 90.0 | 0 | 0 |
| 80 | 24.5 | 254 | 42 | 16.5 ± 0.8* | 249 | 29 | 11.6 ± 1.8 | 213 | 85.5 | 6 | 2.4 ± 1.0† |
| 80 | 34.5 | 146 | 11 | 7.5 ± 1.9* | 140 | 6 | 4.3 ± 1.9 | 129 | 92.1 | 4 | 2.9 ± 3.8† |
| 80 | 41.5 | 152 | 4 | 2.6 ± 1.0 | 145 | 11 | 7.6 ± 2.7 | 131 | 90.3 | 2 | 1.4 ± 0.9 |
Results are presented ±SE.
*
P < 0.001 vs. controls (FET).
†
P < 0.05 vs. controls (FET).