Table 2.

Toxicities reported to be possibly, probably, or definitely related to treatment by at least 10% of those who began treatment

	Previously treated Patients (Cohort 1) n=34		Chemotherapy Naïve Patients (Cohort 2) n=39
Toxicity	Any grade	Grade 3 or 4	Any grade	Grade 3 or 4
Hematologic
neutropenia	59%	41%	59%	28%
thrombocytopenia	41%	0%	44%	5%
leukopenia	26%	15%	21%	3%
lymphopenia	6%	3%	8%	0%
anemia	68%	0%	72%	0%
Non-hematologic
fatigue	56%	3%	72%	3%
nausea	56%	3%	46%	3%
neuro-sensory	47%	0%	33%	5%
vomiting	26%	3%	15%	3%
arthralgia	9%	0%	10%	0%
myalgia	18%	0%	8%	0%
peripheral nerve infection	3%	3%	---	---